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Sanofi Signs a Non-Exclusive Clinical Collaboration Agreement with Mirati to Evaluate Adagrasib + SAR442720 (RMC-4630) in P-I/II Study for KRAS G12C-Mutated Lung Cancer

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Sanofi Signs a Non-Exclusive Clinical Collaboration Agreement with Mirati to Evaluate Adagrasib + SAR442720 (RMC-4630) in P-I/II Study for KRAS G12C-Mutated Lung Cancer

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  • The companies collaborated to evaluate Mirati's adagrasib (KRASG12C inhibitor) + Sanofi's SAR442720 (SHP2 inhibitor) in P-I/II dose-escalation & expansion study in patients with previously-treated NSCLC & KRASG12C mutations
  • Adagrasib & SAR442720 demonstrated an anti-tumor activity in pre-clinical models & both have complementary MoA
  • Sanofi will be responsible for sponsoring & operating the P-I/II study & both companies will share the cost of the study. Additionally- Adagrasib is being evaluated as monothx. and in combination with other anti-cancer therapies in patients with advanced KRASG12C-mutated solid tumors- including NSCLC- colorectal cancer & pancreatic cancer

  | Ref: PR Newswire | Image: Trading View

Click here to­ read the full press release 

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